dcbp 1

dCBP-1 是基于Cereblon 配体的p300 CBP 的选择性双功能降解剂。dCBP-1可以有效的杀死多发性骨髓瘤细胞，并降低驱动 MYC 表达的致癌增强子活性。

Thalidomide-NH-PEG4-COOH is a conjugate comprising an E3 ligase ligand-linker, utilized in the synthesis of dCBP-1. dCBP-1 itself functions as a powerful and selective heterobifunctional degrader targeting p300 CBP.

CBP p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300 CBP.