dbco-nhco-peg-4-amine

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].

DBCO-NHCO-PEG4-amine TFA 是属于PEG类的PROTAC连接子 (PROTAC Linker)。作为一种可降解 (cleavable) 的ADC linker，DBCO-NHCO-PEG4-amine TFA 可用于连接MMAE和抗体。例如，DBCO-VCpAB MMAE和DBCO-TRX MMAE在SKBR3细胞中的EC50分别为280 nM和22 nM。