czh226

CZh226 is a potent and selective PAK4 inhibitor (PAK4 Ki = 9 nM; PAK1 Ki = 3112 nM). CZh226 potently inhibits the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro.

CZh226 hydrochloride 是一种高效且选择性强的PAK4抑制剂，IC50为18 nM，对PAK1的选择性为346倍。由于其口服生物利用度较低，需借助前药PAK4-IN-1来提升吸收率和代谢稳定性。CZh226 hydrochloride 可用于结直肠癌和黑色素瘤的研究。