cytochalasin a

Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy

Cytochalasin O (compound 13)，为P. sp. CIB-109植物病原真菌的次级代谢产物。

Cytochalasin N，一种细胞松弛素，源自内生真菌Phomopsis sp. CIB-109。

Cytochalasin K (化合物7) 是一种IC50为22.58 μM的细胞松弛素，能抑制小麦根系伸长。

Cytochalasin R (compound 17)是从内生真菌拟茎点霉菌sp. xz-18中提取的一种Cytochalasin类似物，表现出潜在的抗真菌活性。

Cytochalasin C is a cell-permeable fungal toxin that can induce the formation of nuclear sticks. Cytochalasin C is 10 times less toxic than cytochalasin D in mice.

Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong

Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) 是肌动蛋白掺入细丝的有效抑制剂。

1-Oleoyl-2-palmitoyl-rac-glycerol (1,2-OP) is a diacylglycerol containing oleic acid at the sn-1 position and palmitic acid at the sn-2 position. It enhances the inhibition of superoxide anion production by cytochalasin B when used at a concentration of 10 μM. The concentration of 1,2-OP decreases from 25.7 to 11.15% during the dry-curing process of Iberian ham.

Sydowinin B is a xanthone polyketide that has been found inA. sydowiiand has immunosuppressant activity.1It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 μg ml, respectively).2Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B and N-Formyl-Met-Leu-Phe with IC50values of 21.2 and 12.62 μM, respectively.3

L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes. L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.

Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).

Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸 cytochalasin B（fMLP CB）产生的超氧阴离子有抑制作用。

2'-Hydroxydaidzein 是一种在植物中发现的异黄酮类植物素，是一种天然化合物。2'-Hydroxydaidzein 具有抗氧化活性，主要由o -氢键解离焓(BDE)和氢原子转移(HAT)机制驱动。2'-Hydroxydaidzein 抑制炎症细胞中的化学介质，可能对治疗和预防与化学介质产生过多有关的中枢和外周炎症性疾病有作用。2'-Hydroxydaidzein 对大鼠中性粒细胞和formyl-Met-Leu-Phe cytochalasin B（fMLP CB）的释放具有抑制作用，IC（50）值分别为2.8+ -0.1和5.9+ -1.4 microM。

Boerelasin E 是第一个自内生真菌 Boeremia exigua 中分离出的具有顺式构型 Δ21(22) 双键的细胞松弛素。其对 MCF-7 细胞的抗增殖活性（IC50=20.52 μM）比顺铂更强。Boerelasin E 通过使 MCF-7 细胞停滞在 G2 M 期并诱导细胞凋亡，来抑制 MCF-7 细胞的完全分裂。