cp5v

CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL VBC complex for ubiquitination followed by proteasomal degradation.

Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V.

Bis-PEG5-acid (PROTAC Linker 36) is a polyethylene glycol (PEG) linker employed for the synthesis of CP5V, a PROTAC that selectively degrades Cdc20[1].

Apcin A HCL 是 Apcin 衍生物。 它是一种后期促进复合物 (APC) 抑制剂。它与 Cdc20 强烈相互作用，并抑制 Cdc20 底物的泛素化。它可用于合成 PROTAC CP5V。