CoumermycinA1 is a JAK2 signal activator. CoumermycinA1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. CoumermycinA1-induced-JAK2 signal activation increases the mRNA level of SCOS2, but reducea leptin receptor mRNA level[1]. [1]. Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR JAK2 AMPK Signaling Pathway in Mouse Adipocytes. Research Article.