7-O-Geranylscopoletin is a natural coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purposes such as the treatment of chronic rheumatism, antispasmodic, paralysis, hemiplegia, and sti
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm
7-hydroxy Coumarin glucuronide is a 7-hydroxy coumarin phase II metabolite that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism.
7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.
Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide.It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM s) than hydrogen peroxide (k =1.5 M s) and moderately faster rate than hypochlorous acid. Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation emission maxima of 332 470 nm, respectively.
Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide. Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation emission maxima of 332 470 nm, respectively.