coumarin boronic acid

Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide.It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM s) than hydrogen peroxide (k =1.5 M s) and moderately faster rate than hypochlorous acid. Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation emission maxima of 332 470 nm, respectively.

Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide. Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation emission maxima of 332 470 nm, respectively.