copper tripeptide

Copper tripeptide (GHK-Cu) 是天然存在的三肽，首先从人血浆中分离，但也能够在唾液和尿液中发现。它能够提高成纤维细胞中胶原蛋白，弹性蛋白，蛋白多糖和糖胺聚糖中信使 RNA 的产生。在伤口愈合期间，它能够通过蛋白水解从现有的细胞外蛋白质中除去，并且用作炎性和内皮细胞的化学引诱物。它是皮肤再生中多种细胞途径的天然调节剂。

AHK-Cu 是一种生物活性肽，具促进毛发生长功能，已作为化妆品成分使用。

GHK-Cu acetate, a complex of the tripeptide Gly-His-Lys and a copper(II) ion, exhibits wound healing and anti-inflammatory properties. It enhances fibroblast proliferation, collagen production, and the release of pro-matrix metalloproteinase-2 (MMP-2) and glycosaminoglycans (GAGs), while also increasing decorin expression in rat wound tissue. Furthermore, at a concentration of 10 µM, it reduces levels of reactive oxygen species (ROS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) in LPS-stimulated RAW 264.7 cells. Additionally, GHK-Cu at 10 µg g mitigates LPS-induced reductions in lung superoxide dismutase (SOD) activity and glutathione (GSH) levels, decreases the accumulation of cells and total protein in bronchoalveolar lavage fluid (BALF), and thus, attenuates acute lung injury in mice.