compound 48/80

Compound 48/80是一种组胺释放剂，通过激活肥大细胞表面的G蛋白偶联受体，提高细胞内钙离子浓度并激活phospholipase D，诱导细胞脱颗粒和类过敏性休克等炎症。

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。

S-777469 是一种选择性的、口服具有活力的大麻素 2 型受体(CB2)激动剂 (Ki: 36 nM)。S-777469 能够剂量依赖性地明显抑制化合物 48/80 诱导的小鼠抓挠行为。S-777469 兴奋 CB2，抑制瘙痒信号的传递，显示出止痒效果。

Escin IIB 是从七叶树 (Aesculus hippocastanum L.) 种子中分离得到的天然皂苷化合物，在动物模型中对急性炎症有研究价值。Escin IIB 还显示出显著的胃黏膜保护作用，可显著减轻乙醇诱导的胃黏膜损伤，在前临床研究中为抗炎机制及胃黏膜防御途径的研究提供潜在工具。

Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell li

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching