compound 48/80

Compound 48/80是一种组胺释放剂，通过激活肥大细胞表面的G蛋白偶联受体，提高细胞内钙离子浓度并激活phospholipase D，诱导细胞脱颗粒和类过敏性休克等炎症。

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。

S-777469 是一种选择性的、口服具有活力的大麻素 2 型受体(CB2)激动剂 (Ki: 36 nM)。S-777469 能够剂量依赖性地明显抑制化合物 48 80 诱导的小鼠抓挠行为。S-777469 兴奋 CB2，抑制瘙痒信号的传递，显示出止痒效果。

Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice.

Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48 80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell li

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48 80-induced MRGPRX2 activation and scratching