chlorpyrifos-oxon

Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a powerful phosphorylating agent with potent inhibition of AChE activity. It induces cross-linking between tubulin subunits and disrupts microtubule function[4].

Chlorpyrifos (diethyl-D10)是Chlorpyrifos 的氘代化合物。Chlorpyrifos的CAS号为2921-88-2。Chlorpyrifos是一种亚硫磷类的有机磷酸酯杀虫剂。它的氧代谢产物是AChE抑制剂，可影响昆虫，人类和其他动物的神经功能。Chlorpyrifos oxon (CPO)代谢物可被血浆酶对氧磷酶 1 (PON1)水解，PON1 的过表达减轻了与 CPO 暴露相关的神经毒性。