chk-in-1

CHK-IN-1 是一种具有抗增殖活性的 CHK1 和 CHK2 双重抑制剂。

CHK1-IN-3 是一种检测点激酶 (CHK1) 抑制剂，IC50 值为 0.4 nM。

CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).

CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.

Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].

Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.

CHK-336（Example 1）为口服活性LDHA抑制剂（IC50＜1 nM），有效抑制小鼠肝细胞产生乳酸。该化合物适用于高草酸尿症相关研究。

CBP501 Affinity Peptide为Chk激酶抑制剂，具有消除DNA损伤剂诱导的G2停滞作用，主要应用于癌症研究领域。

FLT3/CHK-IN-1（Compound 18）为FLT3/CHK1双重抑制剂，其对c-KIT的选择性超1700倍，同时显著降低对hERG的亲和力，IC50为58.4 μM。在MV-4-11细胞接种小鼠异种移植模型中有效抑制肿瘤生长。