chip

YL-109是一种抗肿瘤剂，可以通过芳烃受体 AhR 信号传导诱导 Hsp70 相互作用蛋白 (CHIP) 表达，具有抑制乳腺癌细胞生长和侵袭性的能力。

Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione i

Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate)(736171-62-3 free base) 是一组含有四肽重复 (TPR) 的蛋白质，已显示与 70 kDa 热休克同源蛋白 (hsc70) 的 C 末端结构域相互作用。在本研究中，含 TPR 的蛋白质，包括 hsc70 相互作用蛋白 (CHIP)、TPR1 和人富含谷氨酰胺的 TPR 含蛋白 (hSGT) 的 C 端，对 DnaJ 和 hsc70 对荧光素酶重折叠的影响进行了调查。

Diptoindonesin G is an ERß stabilizer that regulates the stability of ERα and ERß by targeting CHIP E3 ubiquitin ligase. Diptoindonesin G could significantly increase the protein stability of ERß, and reduce the protein level of ERα,

Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.

FUBP1-IN-2 是一种有效的 FUBP1(远上游结合蛋白 1) 抑制剂。在凝胶移位试验中，FUBP1-IN-2 抑制 KH4 FUBP1-FUSE 相互作用。FUBP1-IN-2 在 ChIP 试验中与 FUBP1 结合。FUBP1-IN-2 可降低 c-MycmRNA 和蛋白表达，增加 p21mRNA 和蛋白表达，并消耗细胞内多胺。

WBC100（14-D-Valine-TPL），一款高效、选择性和具口服活性的c-Myc小分子降解剂，通过针对泛素E3连结酶CHIP介导的26S蛋白酶体途径实现其作用。主要应用于c-Myc过表达肿瘤的研究领域。

A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus