Anti-SMARCA4 Antibody (8O968) is a Rabbit antibody targeting SMARCA4. Anti-SMARCA4 Antibody (8O968) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP,ChIP.

IgG

8O968

Human,Mouse,Rat

WB: 1:1000-5000; IHC-P: 1:200-800; IHC-Fr: 1:200-800; ICC/IF: 1:100-500; IF: 1:200-800; IP: 1:20-100; ChIP: 1:20-100

Monoclonal

A synthesized peptide: human SMARCA4

Human

SMARCA4

Transcription activator BRG1

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.