cdk8/19 in 1

CDK8 19-IN-1 is a selective and oral bioavailable CDK8 19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).

SNX7886为高效CDK8 19蛋白降解剂，在293细胞中可分别降解CDK8与CDK19至90%及80%。