cb-1 antagonist 1

CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, and gastrointestinal disorders, psychosis, and cardiovascular.

CB1 antagonist 2 (AM4113) 是一种 caimabinoid 1 拮抗剂，在体内抑制 CB1 的IC50值为 25.5 nM。

O-2050 是一种高亲和力的大麻素CB1受体拮抗剂，Ki 为 2.5 nM。O-2050 抑制大麻素 CB2受体，Ki 为 0.2 nM。O-2050 减少了小鼠的食物摄入量，并且引起小鼠运动。

PGN36 (Compound 18) is a potent and highly selective antagonist of the cannabinoid CB 2 receptor (CB 2 R). It exhibits exceptional affinity for CB 2 R, with a Ki value of 0.09 μM [1].

CB-52为CB2大麻素受体的配体及中性拮抗剂。