calcitonin gene-related peptide receptor

Rimegepant (BMS 927711) 是一种有效的降钙素基因相关肽 (CGRP) 受体拮抗剂 (Ki=0.027 nM，IC50=0.14 nM)。Rimegepant 可同时用于偏头痛急性发作治疗及预防性治疗。

Olcegepant (BIBN-4096) 是一种选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50=0.03 nM，Ki=14.4 pM。

Ubrogepant (MK-1602) 是新型的、口服有效的降钙素基因相关肽受体拮抗剂。Ubrogepant 有潜力用于急性偏头痛的相关研究。

MK-3207 Hydrochloride (MK-3207 HCl) 是口服具有活力的CGRP receptor 拮抗剂，IC50=0.12 nM，Ki=0.024 nM。

Vazegepant hydrochloride (Vazegepant HCl) 是一种用于偏头痛的鼻用 gepant，是一种高度亲和性CGRP 受体拮抗剂 (hCGRPKi=0.023 nM)。它可能有助于有效管理 COVID-19 相关肺部炎症。

Calcitonin (salmon) 是一种阿米林和卡西宁受体的双激动剂，是一种钙调节激素，能够刺激骨的生成并能抑制骨吸收。

Atogepant (MK-8031) 是一种可口服且具有选择性和高效性的降钙素基因相关肽受体 (CGRP) 拮抗剂，可用于研究偏头痛。

Olcegepant hydrochloride (奥塞吉泮盐酸盐，BIBN-4096 hydrochloride)是一种选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50=0.03 nM，Ki=14.4 pM。

Telcagepant（MK-0974，替卡吉泮）是一种口服的降钙素基因相关肽受体（CGRP, calcitonin gene-related peptide）拮抗剂，阻断CGRP受体并减少中枢神经系统的神经传递，用于研究偏头痛和减轻疼痛。

CGRP antagonist 7 是一种有效的降钙素基因相关肽受体 (CGRP) 拮抗剂，其 Ki 值为 0.029 nM。它能抑制 CGRP 受体介导的环磷酸腺苷 (cAMP) 产生，IC50 为 1.5 nM。CGRP antagonist 7 可用于偏头痛研究。

MK-3207是一种高效口服生物可利用的降钙素基因相关肽（CGRP）受体小分子拮抗剂，对人受体体外IC50为0.12 nM，Ki为0.024 nM，并对人AM1、AM2、CTR和AMY3受体表现出卓越选择性，但对犬类和啮齿类等物种的CGRP受体亲和力较低。体外研究证实其能强效拮抗人和恒河猴CGRP受体（K(i) = 0.024 nM），体内模型显示其可浓度依赖性地抑制皮肤血管舒张，阻断50%和90%血流量增加所需血浆浓度分别为0.8 nM和7 nM。

BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.

Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 = 0.166 nM). Salmon calcitonin inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 = 0.003 pg/mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 = 33.9 mg/kg). Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Paget's disease.

Vazegepant (Zavegepant) 是一种可口服且具有选择的降钙素基因相关肽 CGRP 受体拮抗剂，可缓解疼痛，可用于研究偏头疼。

HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.

4991W93 is a 5HT(1B/1D) receptor partial agonist, inhibiting electrically induced plasma extravasation, blocking neurogenic plasma protein extravasation, inhibiting release of calcitonin gene-related peptide.

(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) 是Atogepant 的异构体.Atogepant 是降钙素基因相关肽受体 (CGRP) 拮抗剂。Atogepant 可用于研究偏头痛。

[Tyr22]CalcitoninGene Related Peptide, (22-37), rat 是一种大鼠降钙素基因相关肽 (CGRP) 的 22-37 片段，靶向CGRP 受体和腺苷酸环化酶。降钙素 (calcitonin) 主要由甲状腺 C 细胞产生，而 CGRP 则分泌并储存在神经系统中。

HCGRP-(8-37) acetate 是一种人降钙素基因相关肽 (hCGRP) 片段醋酸盐，也是 CGRP 受体的拮抗剂。

CGRP (83-119), rat TFA (Calcitonin Gene Related Peptide(83-119), rat TFA) 是一种由 37 个氨基酸组成的神经肽降钙素家族，通过降钙素受体样受体起作用。

Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor.

Adrenomedullin 11-50 rat is a peptide fragment of adrenomedullin that possesses systemic vasodilator activity at the level of calcitonin gene-related peptide-1 (CGRP1) receptor activation. Adrenomedullin and its peptide may be used in bone growth studies.

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.

Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin recept