calcitonin , salmon

Calcitonin (8-32), salmon, is a highly selective amylin receptor antagonist. Calcitonin, a hormone involved in calcium and phosphorus metabolism, is primarily produced by the parafollicular or C cells in the thyroid gland of mammals.

Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 = 0.166 nM). Salmon calcitonin inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 = 0.003 pg mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 = 33.9 mg kg). Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Paget's disease.

Calcitonin (salmon) 是一种阿米林和卡西宁受体的双激动剂，是一种钙调节激素，能够刺激骨的生成并能抑制骨吸收。

Calcitonin(salmon)Acetate (47931-85-1(free base))(Salmon calcitonin) 是一种钙调节激素，用于治疗绝经后至少 5 年的女性骨质疏松症。

Dodecanoylcarnitine（(-)-Lauroylcarnitine） 和脂肪酸氧化紊乱有关，使用 Dodecanoylcarnitine 可使鲑鱼降钙素的通透性增加。

Calcitonin-13CIC6,15NIC4(salmon) (Salmon calcitonin-13CIC6,15NIC4) TFA 是一种用13C和15N标记的Calcitonin(salmon)。该化合物作为一种钙调节激素具有双重功能，既作为胰岛淀粉样肽也是降钙素受体的激动剂，其主要功能在于促进骨骼形成及降低骨吸收的过程。

Lauroylcarnitine chloride 可促进大鼠吸收鲑鱼降钙素，在测定原位生物利用度中，提高荧光黄的利用度，降低结肠中 claudin-4 蛋白的表达。