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c20 ceramide

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  • C20 Ceramide
    N-Arachidoyl-D-sphingosine, C20神经酰胺
    T408497344-02-7
    C20 Ceramide (N-Arachidoyl-D-sphingosine) 是一种存在于大脑中的 20:0 神经酰胺,可穿越血脑屏障激活小胶质细胞,诱导抑郁样行为。
    • ¥ 297
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  • C6 Urea Ceramide
    T36321486991-52-0
    C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days. |1. García-Barros, M., Coant, N., Kawamori, T., et al. Role of neutral ceramidase in colon cancer. FASEB J. 30(12), 4159-4171 (2016).
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