bvb 808

Ofloxacin HCl is a synthetic fluoroquinolone ( FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.

BVB808 (NVP_BVB808) 作为一种JAK2选择性抑制剂,在体外对JAK2的选择性约为其它JAK家族成员(如JAK1、JAK3或TYK2)的10倍.该化合物能够抑制JAK2的活性,并减少STAT5的磷酸化,有效阻断JAK2依赖的细胞增殖及存活信号通路.BVB808主要应用于癌症相关的研究领域.

BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2 kinases are turning into therapeutic strategies for treatment of chronic myelogenous leukemia (CML).