brexpiprazole d8

Brexpiprazole D8 (OPC-34712 D8) is a deuterium-labeled Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Ki: 0.12 nM and 0.3 nM).

Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium-labeled Brexpiprazole S-oxide, the primary metabolite of Brexpiprazole, which is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM).

DM-3411-d8 是 DM-3411 的氘代化合物。DM-3411 的 CAS 号为 913611-97-9。Brexpiprazole是人5-HT1A和多巴胺受体的部分激动剂，Ki分别为0.12 和 0.3 nM。它也是5-HT2A受体的拮抗剂，Ki为 0.47 nM，可作为非典型抗精神病药。