bms1166

BMS-1166 是 PD-1 PD-L1免疫检查点抑制剂。它促使 PD-L1 形成 PD-L1 同源二聚体，进而阻断其与 PD-1 的相互作用，其 IC50为 1.4 nM。它阻断了 PD-1 PD-L1 免疫检查点对 T 细胞活化的抑制作用。

Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM). BMS-1166 hydrochloride is an inhibitor of PD-1 PD-L1 interaction (IC50: 1.4 nM). BMS-1166 rivalries the inhibitory effect of PD-1 PD-L1 immune checkpoint on T cell activation.

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 是一种基于间苯二酚二Ph醚支架的程序性细胞死亡-1（PD-1） 程序性细胞死亡配体1（PD-L1）抑制剂, 抑制 PD-1 PD-L1 相互作用，IC50 值为 39.2 nM.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 包含靶蛋白 PD-1 PD-L1 配体和 PROTAC linker。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可用于合成 PROTAC PD-1 PD-L1 degrader-1。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 具有抗癌活性。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可作为稀释剂，用于用于直接压缩制备片剂。

BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1 PD-L1 degrader-1, which facilitates the degradation of PD-1 PD-L1. BMS-1166 demonstrates potent inhibition of PD-1 PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1 PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation.

BMS-1166-N-piperidine-CO-N-piperazine is a chemical compound that contains a PD-1 PD-L1 immune checkpoint ligand and a PROTAC linker. It can be utilized in the synthesis of PROTAC PD-1 PD-L1 degrader-1, which effectively inhibits the PD-1 PD-L1 interaction, demonstrating an IC50 value of 39.2 nM.