bis-peg-tfp ester

Bis-PEG-TFP ester (MW 5000) is a polyethylene glycol (PEG) based linker compound utilized for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].

Bis-Mal-Lysine-PEG4-TFP ester, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

Bis-PEG25-TFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG6-TFP ester 是一种 PEG 连接体，带有两个末端 TFP 酯基。TFP 酯具有胺反应性，相较于 NHS 酯具有更高的稳定性和更低的水解速度。PEG 链的存在提高了化合物在水性介质中的溶解性，并且随着 PEG 链的增加，溶解性进一步增强。