bis-mal-peg-7

Bis-Mal-PEG7 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG4-bis-PEG3-methyltetrazine, a cleavable 7-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-PEG4-bis-PEG3-DBCO 是一种含有七个 PEG 单元的可降解ADC linker，主要用于合成抗体偶联活性分子 (ADC)。此外，作为点击化学试剂，Mal-PEG4-bis-PEG3-DBCO 包含 DBCO 基团，能够通过菌株促进的炔-叠氮环加成反应 (SPAAC) 与含 Azide 基团的分子发生反应。