biglen acetate

BigLEN (mouse) acetate 是一种有效的、选择性的孤儿 G 蛋白偶联受体 171 (GPR171) 激动剂，Kd 为 ~0.5 nM。

GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.