biglen

GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.

BigLEN (mouse) acetate 是一种有效的、选择性的孤儿 G 蛋白偶联受体 171 (GPR171) 激动剂，Kd 为 ~0.5 nM。

BigLEN(rat)是一种有效的GPR171激动剂，其EC50为1.6 nM。

BigLEN(mouse) TFA 是一种GPR171激动剂，同时也是源自proSAAS的神经肽。该化合物调节小鼠的食物摄入，并且依赖于突触后G蛋白的激活，抑制谷氨酸释放到下丘脑室旁核的旁核细胞上。