bicyclic

Bicyclic UK18 为一种竞争性抑制剂，作用于人类尿激酶型纤溶酶原激活剂 (uPA)，其抑制常数 (Ki) 为 53 nM。

GRK5-IN-2 是基于吡啶的双环化合物，抑制 G 蛋白偶联受体激酶 5 。它调节胰岛素的表达和 或释放，在代谢疾病中有研究价值。

Sabinene 是香料添加剂，具有成为下一代飞机燃料成分的成分。

3-Carene（Delta-3-Carene） 是西部落叶松和花旗松中提取的双环单萜烯，可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用，能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。

Citalopram hydrobromide (XU-62-320) 是一种选择性 5-羟色胺再摄取抑制剂，可选择性地抑制 CNS 神经元对 5-羟色胺的再摄取，从而增强中枢神经系统中的 5-羟色胺能活性，也具有抗抑郁活性。它抑制兔血小板中 5-HT 的摄取，IC50为 14 nM。

Camphor (2-Camphanone) 是一种双环单萜酮，广泛存在于植物中，尤其是樟脑。 它是一种激动剂，局部用作皮肤止痒剂和抗感染剂，具有抗病毒，镇咳和抗癌活性。

Bicyclohexyl是一种具有双环结构的有机化合物，广泛应用于生物化学实验和药物合成研究。

Indole 它具有双环结构，由一个六元苯环和一个五元含氮吡咯环融合而成。它可以由细菌作为氨基酸色氨酸的降解产物产生。它自然存在于人类粪便中，有强烈的粪便气味。然而，在非常低的浓度下，它有一种花香，是许多花香(如橙花)和香水的成分。

(+)-BORNEOL (d-Borneol) 是一种天然的双环单萜，在中药中用于镇痛和麻醉；增强 GABA 受体活性，EC50 为 248 μM。

1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.

Phalloidin 是一种在鹅膏菌中发现的双环七肽，参与 F-肌动蛋白染色。 Phalloidin 是一种肌动蛋白不可逆聚合成微丝的化合物。Phalloidin 可干扰细胞的运动和生长，可用于标记脑血管。

Fmoc-Dap(Boc)-OH 为一种氨基酸衍生物，其结构中包含 Fmoc 保护基团，主要用于合成双环肽速激肽NK2拮抗剂。

RA VII is used as an antitumor bicyclic hexapeptide of plant origin.

Salinamide A is an effective anti-inflammatory bicyclic depsipeptide.

LY 173013 is a bicyclic pyrazolidinone, it has antibacterial properties.

LY 186826 is an antibacterial agent with bicyclic pyrazolidinone properties.

Valnivudine 是 CF-1743 的前体，是一种口服有效和高效的抗带状疱疹 (HZ) 核苷类似物, 是一种双环核苷类似物 (BCNA). Valnivudine 具有抗病毒活性，可对水痘带状疱疹病毒 (VZV) 进行高度抑制。Valnivudine 在体内可以迅速广泛地转化为 CF-1743。

Decalin (decahydronaphthalene, also known as bicyclo[4.4.0]decane), a bicyclic organic compound, is an industrial solvent. A colorless liquid with an aromatic odor, it is used as a solvent for many resins or fuel additives. It is the saturated analog of n

Drimane is a bicyclic sesquiterpene. It is the parent structure of many natural products with various biological activity.

2'-O,4'-C-Methyleneuridine 是一种具有典型 C3'-endo 糖缩皱的新型双环核苷类似物。

Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.

O-Benzylhydroxylamine is a building block.1,2It has been used in the synthesis of β-lactam inhibitor precursors and fluoroquinolone derivatives with antibiotic activity. 1.Bellettini, J.R., and Miller, M.J.A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitorsTetrahedron Lett.38(2)167-168(1997) 2.Asadipour, A., Moshafi, M.H., Khosravani, L., et al.N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluationDaru.26(2)199-207(2018)

3-Butenoic acid, also known as Vinylacetic acid, is utilized in the synthesis of 3,6-dihydro-1,2-oxazine that possesses a bicyclic structure. This strained bicyclic compound, when combined with an external alkene, acts as a reactive substrate in domino metathesis reactions.

SOS1-IN-5 是一种嘧啶双环衍生物，是一种 SOS1 的有效抑制剂。SOS1-IN-5 能够干扰 RAS-SOS1相互作用，进而阻断 KRAS 的激活，表现出广谱抑制 KRAS 活性作用。SOS1-IN-5 对癌症疾病表现出研究潜力。