betulinic acid derivative-1

Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM.

2,3-Indolobetulinic glycine amide is a pentacyclic triterpene and derivative of betulinic acid .1It has been used in the synthesis of betulinic acid derivatives with anticancer activity. 1.Kumar, V., Rani, N., Aggarwal, P., et al.Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivativesBioorg. Med. Chem. Lett.18(18)5058-5062(2008)

N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1 1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017)

RPR103611，一个桦木酸衍生物，作为HIV-1入侵抑制剂表现出高效性，其对CCR5（热带）病毒YU2、CXCR4（热带）病毒NL4-3及双热带病毒89.6的IC50分别达到80、0.27和0.17。

RORγ antagonist1 (化合物22) 作为RORγ的有效拮抗剂 (KD=0.18 μM)，在HPAF-II胰腺癌异种移植模型中显示出了抗增殖性能。该化合物通过抑制RAS MAPK和AKT mTORC1通路，并引发caspase依赖的细胞凋亡(apoptosis)机制，从而在胰腺癌细胞中发挥作用。