betulinic acid

Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。

Betulinic acid (Mairin; Gratiolone; Platanol) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131503。

Betulinic acid propargyl ester is a pentacyclic lupane triterpene and alkyne derivative of betulinic acid .1,2It has been used in click chemistry reactions for the synthesis of cytotoxic anticancer betulinic acid derivatives.

Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM.

Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.

Betulinic acid palmitate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5987，CAS号为 19833-15-9。

Epibetulinic acid 对细菌内毒素刺激的小鼠巨噬细胞 (RAW 264.7) 中 NO 和前列腺素 E(2) 的产生具有有效的抑制作用，IC50分别为 0.7 和 0.6 μM，具有抗炎活性。

Dihydrobetulinic acid is a bioactive chemical.

23-Hydroxybetulinic acid (Anemosapogenin) 是一种具有抗癌作用的生物化合物。

Gamibetal (4-Amino-3-hydroxybutyric Acid) 是 γ-氨基-β-羟基丁酸，对癫痫具有潜在的研究价值。

Betulin (betulinol) 是从桦树树皮中分离出来的一种天然三萜，是 SREBP 抑制剂。

NVX-207 is a derivative of betulinic acid. It has anti-cancer activity.

Lup-20(29)-en-28-oic-3-O-beta-glucopyranosyl(2-1)-O-beta-glucopyranoside is a betulinic acid glycoside from Schefflera venulosa.

2,3-Indolobetulinic glycine amide is a pentacyclic triterpene and derivative of betulinic acid .1It has been used in the synthesis of betulinic acid derivatives with anticancer activity. 1.Kumar, V., Rani, N., Aggarwal, P., et al.Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivativesBioorg. Med. Chem. Lett.18(18)5058-5062(2008)

N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1 1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017)

Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activity, could be attributed due to PTP

RPR103611，一个桦木酸衍生物，作为HIV-1入侵抑制剂表现出高效性，其对CCR5（热带）病毒YU2、CXCR4（热带）病毒NL4-3及双热带病毒89.6的IC50分别达到80、0.27和0.17。

RORγ antagonist1 (化合物22) 作为RORγ的有效拮抗剂 (KD=0.18 μM)，在HPAF-II胰腺癌异种移植模型中显示出了抗增殖性能。该化合物通过抑制RAS/MAPK和AKT/mTORC1通路，并引发caspase依赖的细胞凋亡(apoptosis)机制，从而在胰腺癌细胞中发挥作用。

Betulinic glycine amide, a pentacyclic triterpenoid derivative of betulinic acid, serves as a precursor for synthesizing derivatives with anticancer and antiviral activity.

Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vitro activity against the chloroquine