bch189

Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂，可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。

Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that effectively inhibits the reverse transcriptase activity of both HIV 1/2 and hepatitis B virus. Moreover, it demonstrates the ability to penetrate the central nervous system [1] [2].

Lamivudine, (+/-)-trans- is a reverse transcriptase inhibitor and zalcitabine analog. It is used for the treatment of hepatitis B (HBV) and Human Immunodeficiency Virus Type 1 (HIV-1).

Lamivudine 13C,15N2, an impurity of Lamivudine (BCH-189), functions as an inhibitor of both HIV-1/2 reverse transcriptase and hepatitis B virus reverse transcriptase, classifying it as a nucleoside reverse transcriptase inhibitor (NRTIs).

Lamivudine triphosphate (3TCTP)是Lamivudine(核苷类似物)的磷酸化形式.该化合物能够抑制HIV或HBV的逆转录酶,通过链终止机制防止病毒复制.此外,Lamivudine triphosphate亦作为HCVNS5B RdRp亚基的抑制剂,且可被SARS-CoV-2 RdRp整合入新合成的RNA中,有效阻断新生SARS-CoV-2 RNA的突变.

Lamivudine-13C-d2 是 Lamivudine 的 13C 和氘代化合物。Lamivudine 的 CAS 号为 134678-17-4。Lamivudine 是一种核苷逆转录酶抑制剂，可抑制HIV逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。