azd 9164 bromide

AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. AMG-221 decreased fed blood glucose and insulin levels

AZD-9164，一种muscarinic M3 receptor antagonist，被开发用于治疗慢性阻塞性肺病（COPD）。AZD-9164旨在通过改善肺功能的幅度和持久性而不增加系统性不良事件，可能超越tiotropium的治疗指数。