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  • ay 254
    T411892093408-03-6
    AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1 2 signaling (EC50= 2 nM for ERK1 2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3 8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.
    • ¥ 10600
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