AvermectinB1a aglycone is an aglycone form of the anthelmintic and insecticide avermectinB1a . It hyperpolarizes P. crassipes muscle fibers with a minimum active concentration (MAC) value of 0.1 μM. AvermectinB1a aglycone decreases survival of C. elegans (MAC = 0.1 μM). In vivo, avermectinB1a aglycone prevents seizures induced by pentylenetetrazole in mice (ED50 = 43.9 mg/kg) without inducing deficits in rotarod performance.
AvermectinB1a monosaccharide is a macrolide anthelmintic and monosaccharide form of avermectinB1a . It is lethal to C. elegans with a minimum active concentration (MAC) value of 0.1 μM. AvermectinB1a monosaccharide also stimulates conductance in isolated shore crab muscle.