autophagy-targeting chimeras

TSPO ligand-2 (Carbonic acid) 是 AUTAC1 的配体，AUTAC1含有一个对氟苄基鸟嘌呤和一个烟曲霉醇部分。

J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.

Cys-C-cGMP 为一种AUTACs自噬标签。它能够促进HeLa细胞线粒体K63链式连接的泛素化增加。

2G-HaloAUTAC (Compound tt44)，作为第二代自噬靶向嵌合体，通过替换L-半胱氨酸 (L-Cys) 连接子的结构进一步优化了其活性。该化合物依靠自噬机制，有效降解EGFP-HaloTag蛋白。