astressin

Astressin is an amino-terminal truncated analog of CRF that retains high affinity binding to the extracellular domain of the receptor and is believed to act as a neutral competitive antagonist of receptor activation.

Astressin acetate 是促肾上腺皮质激素释放因子 (CRF) 的拮抗剂，对 CRF 结合蛋白具有低亲和力，对克隆垂体受体具有高亲和力 (Ki = 2 nM)。

Potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying.

Corticotropin-releasing factor (CRF) receptor agonist. Ki values are 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b respectively.

Sauvagine acetate(74434-59-6 Free base) 是一种促肾上腺皮质激素释放因子 (CRF) 受体激动剂。 抑制 125I-[D-Tyr1]astressin 与 hCRF-R1、rCRF-R2a 和 mCRF-R2b 结合的 Ki 值分别为 9.4、9.9 和 3.8 nM。