ascochlorin

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, primarily exerts its anti-tumor properties by inhibiting the STAT3 signaling pathway. It induces apoptosis and possesses anti-inflammatory activity[1][2][3].

Ascochlorin A is a novel and potent hDHODH inhibitor ( K D = 3.29 μM) for treatment of triple-negative breast cancer.

4-O-Methyl-ascochlorin (Compound MAC) 是Ascochlorin的一个衍生物。它能够选择性诱导K562白血病细胞的凋亡（apoptosis），导致G1期阻滞，并下调c-Myc的表达。此外，4-O-Methyl-ascochlorin 还可促进AMPK的磷酸化，同时抑制mTOR及其靶蛋白（如p70S6 K和4E-BP-1）的磷酸化。该化合物可用于白血病研究。