arginases ii

Arginase inhibitor 1 is a potent inhibitor of human arginases I and II (IC50s: 223 and 509 nM).

CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).

NED-3238 is a highly potent inhibitor of arginase I and II (IC50 of 1.3 nM and 8.1 nM, respectively).

Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) 是大黄的一种活性成分，通过抑制精氨酸酶活性激活内皮细胞一氧化氮合酶，抑制Arginase I 和Arginase II，IC50值分别为 11.22 和 11.06 μM。它可增加肺血氧分压，减少肺间质水肿，从而保护肺损伤。