apetx-2

Acid-sensing ion channel 3 (ASIC3) channel blocker (IC50 values are 63 and 175 nM for homomeric rat and human ASIC3 channels). Also inhibits NaV1.8 and NaV1.2 channels (IC50 values are 55 and 114 nM respectively). Demonstrates analgesic properties against

APETx2 TFA 是可来自Anthopleura elegantissima 的海葵肽，是选择性的、可逆的酸敏感的离子通道ASIC3 (acid-sensing ion channel)抑制剂，其 IC50值为 63 nM. APETx2 作用在ASIC3 通道外部。APETx2 TFA 能够逆转酸性诱导的炎症疼痛。