antitumor agent 28

Antitumor agent-28 is a compound that specifically targets and inhibits the activity of the ataxia telangiectasia mutated (ATM) kinase. By doing so, it effectively impedes the progression of ATM-mediated diseases and demonstrates significant anti-cancer activity.

Antitumor agent-191 (Compound 7) 对HSV-1和HIV展示抗病毒活性，EC50分别为0.03 μM和0.81 μM。此外，该化合物具有抗肿瘤潜能，能够抑制HepG2、WI-38、Vero和MCF-7癌细胞，其IC50分别为19.6 μM、39.3 μM、18.3 μM和28 μM。

Antitumor agent-23 exhibits potent antitumoral activity, as demonstrated by its GI50 values of 38, 48, 5, 27, 80, and 28 nM against the lymphoma cell lines GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI respectively.

Antitumor agent-172 (Compound 28)，作为β-catenin BCL9相互作用的抑制剂，展示了IC50值为3.92 μM的效果。其对β-catenin的高亲和性体现在Kd值仅为82 nM。此外，Antitumor agent-172 能够有效激活T细胞和促进抗原呈递，同时在小鼠模型中显示出显著的抗肿瘤活性及优异的药代动力学属性。