anthracis

Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg mL 和 0.25 μg mL。

Coreoside B 是从coreoside 中分离出来的，对金黄色葡萄球菌和炭疽杆菌显示出较弱的抗菌活性。

Ciprofloxacin (Bay-09867) 是一种有高抗菌活性的氟喹诺酮类抗生素。

GC-072是一种效力强大的4-oxoquinolizine类抗生素，具备选择性抑制细菌拓扑异构酶的能力。GC-072能够在体外对B. pseudomallei的敏感和耐药菌株展示效果，也能抑制Burkholderia mallei、Bacillus anthracis、Yersinia pestis和Francisella tularensis等危险病原体。在模拟小鼠类鼻疽感染的模型中，口服GC-072表现出剂量依赖性的生存优势，显示出其作为类鼻疽口服一线治疗方案的潜力。

Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM, respectively).3 1.Shiomi, K., Iinuma, H., Hamada, M., et al.Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activityJ. Antibiot. (Tokyo)39(4)487-493(1986) 2.Hori, Y., Abe, Y., Shigematsu, N., et al.Napyradiomycins A and B1: Non-steroidal estrogen-receptor antagonists produced by a StreptomycesJ. Antibiot. (Tokyo)46(12)1890-1893(1993) 3.Yamamoto, K., Tashiro, E., Motohashi, K., et al.Napyradiomycin A1, an inhibitor of mitochondrial complexes I and IIJ. Antibiot. (Tokyo)65(4)211-214(2012)

Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus(MICs = <0.05-0.39 μg/ml). Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 μM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 μg/ml, respectively). 1.Chino, M., Nishikawa, K., Umekita, M., et al.Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activitiesJ. Antibiot. (Tokyo)49(8)752-757(1996)

Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus, the fungi T. asteroides and T. mentagrophytes, and P. falciparum. It is also active against a panel of five plant pathogenic fungi. Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts.

Dalbavancin hydrochloride (MDL-63397 hydrochloride)为半合成脂糖肽类抗生素，有效对抗革兰氏阳性菌。其对金黄色葡萄球菌与炭疽芽孢杆菌的MIC90分别为0.06 μg mL与0.25 μg mL。

Raxibacumab (ABthrax) 是一种针对炭疽芽孢杆菌保护性抗原的人源化抗体，具有抗感染活性，可阻断炭疽芽孢杆菌毒素的相互作用，可用于研究炭疽病防治。

CaLL为具抗菌活性的抗菌肽，针对B. anthracis, B. anthracis (vegetative), and B. cepacia表现出MIC为7.8、31.3、31.3 μg mL的效力。

P1是一种具有抗革兰氏阳性菌与抗革兰氏阴性菌能力的广谱抗菌肽，有效针对B. anthracis、耐碳青霉烯类细菌A. baumannii和K. pneumoniae。

(±)-Decursinol (3',4'-dihydro-3'-hydroxy-Xanthyletin) 是来自当归的一种 FtsZ 抑制剂，抑制 B. anthracis 的 FtsZ 聚合，IC50为 102 μM。

Bactobolin A 是一种最初从 Pseudomonas 中分离出的微生物代谢产物，具有抗生素和抗癌活性。它对 S. aureus、S. epidermidis、S. faecalis、B. anthracis、B. subtilis、E. coli、S. typhi 和 S. dysenteriae 活跃(MICs = 0.1-12.5 µg/ml)。在体内，bactobolin A (0.25-4 mg/kg) 提高了 L1210 小鼠白血病模型的存活率。

Clazamycin A是一种最初从链霉菌中分离出的抗生素和微生物代谢产物。它对多种细菌具有活性，包括S. aureus、B. anthracis、B. subtilis、E. coli和P. aeruginosa（MICs分别为100、6.25、100、50和25 µg/ml）。

Antibiofilm agent-9 (Compound 4) 是一种吡咯霉素衍生物，具有显著的抗菌和抗生物膜活性。该化合物能有效抑制Bacillus anthracis，其最小抑菌浓度（MIC）为0.031 μg mL。此外，Antibiofilm agent-9 在含8.0 μg mL浓度下，24小时内生物膜抑制率可达84%。在小鼠模型中，此化合物也展示了优良的药代动力学特性。