ansatrienin a

Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. It is an oxidized form of ansatrienin B .

Ansatrienin A3 is produced by Streptomyces collinus.

Ansatrienin B 是一种 ansamycin 类抗生素及抗真菌剂，最初从 S. collinus 和 S. rishiriensis 中分离获得。Ansatrienin B 可抑制甲状旁腺激素诱导的胎鼠长骨钙释放（IC50 = 21 nM）、pp60c-src kinase（IC50 = 50 nM）以及通过抑制 L-leucine 掺入而抑制蛋白质合成（A549 细胞中 IC50 = 58 nM），同时还可抑制 TNF-α 诱导的 ICAM-1 表达（IC50 = 300 nM）。