angiotensin ii (1 4), human

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers.

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure.

4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.

Angiotensin II human TFA 是肾素-血管紧张素系统中的强效血管收缩剂，通过与 AT1R 和 AT2R 受体作用调节血压，可激活交感神经、促进醛固酮合成和肾功能，诱导血管平滑肌细胞增殖及成纤维细胞中 I 型和 III 型胶原合成，导致血管和心肌增厚、纤维化，并诱导凋亡及促进毛细血管生成，可用于构建心脏肥大、高血压和腹主动脉瘤模型。