ana773

ANA773 is a Toll-like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.

RG-7795是一种小分子前药，其活性成分为toll-like receptor 7 (TLR 7)激动剂。

Npc 12626 is a N-methyl-D-aspartate receptor antagonist; NPC 17742, the (2R,4R,5S)-isomer, is the most potent isomer in the mixture NPC 12626.