amino peg3 ch2cooh

Amino-PEG3-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Fmoc-amino-PEG3-CH2COOH is a polyethylene glycol (PEG)-based linker, primarily employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

CEP1347-VHL-02 作为一种靶向MLK3的PROTAC，具有独特的分子结构。其构成包括靶蛋白配体CEP-1347, E3 泛素连接酶配体(S,R,S)-AHPC-Me, 以及PROTAC Linker Amino-PEG3-CH2COOH。在该化合物中，CEP-1347-acid 用作靶蛋白配体的活性对照，而 (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 则是E3 泛素连接酶配体与Linker 的偶联产物。