Ecopipam (SCH 39166) hydrochloride is a highly potent, selective, and orally active antagonist of dopamine D1 D5 receptors. It exhibits impressive binding affinities, with Ki values of 1.2 nM and 2.0 nM for D1 and D5 receptors, respectively. Ecopipam hydrochloride demonstrates remarkable selectivity, displaying over 40-fold selectivity compared to D2, D4, 5-HT, and α2a receptors, with Ki values of 0.98 μM, 5.52 μM, 0.08 μM, and 0.73 μM, respectively. Its application extends to various areas of research, including schizophrenia, cocaine addiction, and obesity [1] [3].
Fenoldopam hydrochloride is a selective D1-like dopamine receptor partial agonist. It acts as a vasodilator in vivo and does not readily cross the blood-brain barrier. Fenoldopam HCl is also an α2-adrenoceptor antagonist in vitro.
L-Ornithine lactam is a synthetic intermediate. It has been used in the synthesis of dipeptidyl peptidase 4 (DPP-4) inhibitors, as well as signaling peptides.