alltransretinal

All-trans-retinal (Vitamin A aldehyde) 是视网膜中维生素A 代谢物之一。 生理条件下，它再生为视觉发色团，11-顺式-视黄醛。

11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light. In a moth model of carotenoid deficiency-induced low visual sensitivity, 11-cis retinal application to compound eyes restored visual sensitivity almost completely.

9-cis-Retinal 是一种类视黄醇，对细胞视黄醇结合蛋白-I (CRBP-1) 和 CRBP-II 的 Kd 分别为 8 nM 和 5 nM。9-cis-Retinal 加快了视网膜类器官中杆感光细胞的分化和成熟，可降低无配体视蛋白的毒性，可用于研究由G90D视紫红质引起的先天性静止性夜盲症。

Expression system: HEK293 Cells
Length: 1-734, Partial
Activity: Not Tested