ada 07

ADA-07 is a TOPK inhibitor which interacts with TOPK at the ATP-binding pocket and inhibits its kinase activity, thereby suppressing SUV-induced phosphorylation of ERK1 2, p38, and JNKs, and subsequently inhibiting AP-1 activity.

Oditrasertib (DNL-788) 是一种高效的 RIPKl 抑制剂，其 IC50 值低于 100 nM。Oditrasertib 可用于研究多发性硬化症和阿尔茨海默症等免疫系统疾病与神经系统疾病。