act-672125

ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.

Iso-SLR 080811是SLR 080811的异构体，可用于生命科学领域的相关研究。SLR080811是一种选择性的SphK2抑制剂(Ki=1.3 μM)，在野生型小鼠中升高血液中S1P水平，在sphk1缺失型小鼠中降低S1P水平，在SphK2缺失小鼠的S1P水平不变。