ac 253

Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks el

Cyclic AC253 是一种 amylin 受体的拮抗剂，其 IC50 为 0.3 μM。Cyclic AC253 对 Aβ 毒性具有神经保护作用，并能够消除 Aβ 诱导的海马长时程增强损伤。此外，Cyclic AC253 能够穿过血脑屏障。

Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.

cAC 253 acetate (TP2135 Free base) 是 amylin 的拮抗剂，抑制 125I-adrenomedullin 结合，其IC50 值为 25 nM。