a-1210477

A-1210477 是一种选择性的MCL-1有效抑制剂，Ki 值为 0.45 nM。它特异性结合 MCL-1，并以 MCL-1 依赖性方式促进癌细胞凋亡。

A-1210477-piperazinyl is a compound that specifically targets and binds to the protein myeloid cell leukemia 1 (MCL1). This compound is utilized in PROTAC technology, which harnesses the ability to selectively degrade target proteins.

A-1248767，作为MCL-1抑制剂（IC50=23.9 nM; Ki=0.41 nM），展现了抗癌活性。这种化合物是A-1210477的衍生物，能高效结合MCL-1，诱导细胞中MCL-1蛋白水平上升，并推动肿瘤细胞发生凋亡(apoptosis)。